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Novo Nordisk Foundation Symposium - Rethinking Transcription Factors


Date and time

Wednesday August 24, 2022 at 8:00 AM to Friday August 26, 2022 at 1:00 PM

Registration Deadline

Monday August 1, 2022 at 12:00 PM

Location

Novo Nordisk Foundation, Tuborg Havnevej 19, 2900 Hellerup Novo Nordisk Foundation
Tuborg Havnevej 19
2900 Hellerup

Novo Nordisk Foundation Symposium - Rethinking Transcription Factors


Event Description

NNF Symposium - Rethinking Transcription Factors

The Novo Nordisk Foundation and the Department of Biology are pleased to invite you to participate in a three day symposium on transcirption factors and their interactions with special focus on the role of intrinsic disorder. Topics include ensemble characterization, mechanisms, networks, structures, and in vivo function. Accordingly, speakers represent diverse fields such as physics, biochemistry, structural biology, pharmacology, and cell biology. It is a specific aim of the symposium to facilitate intensive discussions among experienced and younger scientists, especially PhD students and postdocs, on central topics as presented by the speakers. Participants are strongly encouraged to bring posters. Based on submitted poster abstracts two younger speakers will be selected for oral presentations.

You are very welcome to advertise the event by printing this poster and putting it on your door. Download the poster here.

A special summer course targeting PhD students is organized in conjunction with the symposium. You can download a flyer for the course here. Accepted applicants for the course receive free seats for the symposium and therefore do not need to register on this page. Instead, please register for the course here.


CONFIRMED SPEAKERS

  • Elisar Barbar - Oregon State University, Corvallis, OR
  • Gijs Wuite - Vrije Universiteit Amsterdam, NL
  • Hagen Hofmann - Weizmann Institute of Science, IL
  • Jesper Svejstrup - University of Copenhagen, Copenhagen, DK
  • Joseph M. Rogers - University of Copenhagen, Copenhagen, DK
  • Lucia C. Strader - Duke University, Durham, NC
  • Madan Babu - St. Jude Children's Research Hospital, Memphis, TN
  • Max Staller - University of California, Berkeley
  • Naama Barkai - Weizmann Institute of Science, IL
  • Per Jemth - Uppsala University, Uppsala, SE
  • Peter E. Wright - The Scripps Research Institute, La Jolla, CA
  • Pétur Orri Heiðarsson - University of Iceland
  • Rachel E. Klevit - University of Washington, Seattle, WA
  • Richard A. Young - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, MA
  • Robert O.J. Weinzierl - Imperial College London, London, UK
  • Sarah Bondos - Texas A&M Health Science Center, Bryan, TX
  • Sarah Shammas - University of Oxford, Oxford, UK
  • Steven Hahn - Fred Hutchinson Cancer Research Center, Seattle, WA
  • Tanja Mittag - St. Jude Children's Research Hospital, Memphis, TN
  • Vaclav Veverka - Institute of Organic Chemistry and Biochemistry, AS CR, Prague, CZ
  • Vincent J. Hilser - Johns Hopkins University, Baltimore, MD
  • Xavier Salvatella - IRB Barcelona, Barcelona, ES
  • Yuan He - Northwestern University, Evanston, IL


TENTATIVE PROGRAM

DAY 1

WEDNESDAY 24

8.00 – 8.30

Registration and light breakfast

8.30 – 8.35

Welcome by the Novo Nordisk Foundation

8.35 – 8.40

Welcome by REPIN

 

 

 

8.40 – 10.25

STRUCTURAL ENSEMBLES AND MECHANISMS

 

8.40 – 9.25

Peter E. Wright, The Scripps Research Institute, La Jolla, CA: Regulation of transcription by posttranslational modification of disordered domains

 

9.25 – 9.45

Selected based on abstracts: Mark Driver, University of Groningen, NL: Elucidating transcription condensate selectivity: a molecular dynamics approach

 

9.45 – 10.25

Per Jemth, Uppsala University, Uppsala, SE: Probing protein-protein interactions using an evolutionary approach

 

 

 

10.25 – 10.50

Coffee break

 

 

 

10.50 – 12.35

COMPLEXES AND FLEXIBILITY IN COMPLEXES

 

10.50 – 11.30

Yuan He, Northwestern University, Evanston, IL: Structural visualization of chromatin regulatory complexes using cryo-EM

 

11.30 – 11.55

Pétur Orri Heiðarsson, University of Iceland, Reykjavík, IS: Disordered domains of pioneer transcription factors in chromatin invading and opening

 

11.55 – 12.35

Rachel E. Klevit, University of Washington, Seattle, WA: Structure/Not Structure: From Fingers to Fuzz

 

 

 

12.35 – 13.25

Lunch

 

 

 

13.25 – 14.45

DNA-BINDING AND GENE SPECIFICITY

 

13.25 – 14.15

Naama Barkai, Weizmann Institute of Science, IL: How transcription-factor recognized their binding sites within large genomes

 

14.15 – 14.55

Steven Hahn, Fred Hutchinson Cancer Research Center, Seattle, WA: Transcription coactivator mechanisms and gene specificity

 

 

 

14.55 – 16.00

Coffee and poster session I

 

 

 

16.00 – 17.05

EMERGING TECHNIQUES

 

16.00 – 16.25

Selected based on abstracts: Alexandre M. Erkine, Butler University, IN: Surfactant mechanism of eukaryotic gene activation

 

16.25 – 17.05

Gijs Wuite, Vrije Universiteit Amsterdam, NL: Frontiers in Single Molecule manipulation and imaging of DNA-protein transactions

 

 

 

17:05 – 18:00

Reception

 

 

 

DAY 2

THURSDAY 25

8.00 – 8.30

Light breakfast

 

 

8.30 – 9.50

DETERMINANTS OF ACTIVATION DOMAINS

 

8.30 – 9.10

Max Staller, University of California, Berkeley, CA: Sequence features of transcriptional activation domains 

 

9.10 – 9.50

Xavier Salvatella, IRB Barcelona, Barcelona, ES: Decoding the sequence determinants of activation domains in transcription factors

 

 

 

9.50 – 10.10

Coffee break

 

 

 

10.10 – 12.10

(ALLOSTERIC) REGULATION IN DNA-BINDING

 

10.10 – 10.50

Vincent J. Hilser, Johns Hopkins University, Baltimore, MD: Frustration in transcription factors provides bi-directional allosteric control. 

 

10.50 – 11.30

Hagen Hofmann, Weizmann Institute of Science, IL: Rethinking DNA - A phenotype switch driven by DNA-mediated allostery

 

11.30 – 12.10

Elisar Barbar, Oregon State University, Corvallis, OR: Protein disorder in transcription factors and gene silencing regulation

 

 

 

12.10 – 13.00

Lunch

 

 

 

13.00 – 14.20

DISORDER IN BINDING AND REGULATION

 

13.00 – 13:40

Sarah Shammas, University of Oxford, Oxford, UK: Roles of protein disorder in DNA binding domains

 

13.40 – 14.20

Robert O.J. Weinzierl, Imperial College London, London, UK: Understanding structure/function relationship in the intrinsically disordered MYC oncoprotein through combined experimental and computational approaches

 

 

 

14:20 – 16:00

Coffee and poster session II

 

 

 

16.00 – 18.00

COMPLEXES, NETWORKS AND REGULATION

 

16.00 –16.40

Jesper Svejstrup, University of Copenhagen, Copenhagen, DK: Rethinking RNA polymerase II, the ultimate transcription factor

 

16.40 –17.20

M. Madan Babu, St. Jude Children's Research Hospital, Memphis, TN: Systems approaches to studying the role of IDRs in transcriptional regulation of gene expression

 

17.20 – 18.00

Vaclav Veverka, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, CZ: The role of IDP regions in nucleosome recognition

 

 

 

 

 

 

DAY 3

FRIDAY 26

8:00 – 8:30

Light breakfast

 

 

8.30 – 9.35

DRUG AND DESIGN

 

8.30 – 9.10

Sarah Bondos, Texas A&M Health Science Center, Bryan, TX: Shape-shifting disorder to regulate and diversify transcription factor function

 

9.10 – 9.35

Joe Rogers, University of Copenhagen, Copenhagen, DK: Rethinking the drug potential of peptides

 

 

 

9.30 – 10:10

Coffee break

 

 

 

10.10 – 12.10

CONDENSATES IN TRANSCRIPTIONAL REGULATION

 

10.10 – 10.50

Lucia C. Strader, Duke University, Durham, NC: Transcription factor condensation attenuates activity and rewires gene expression

 

10.50 – 11.30

Jurian Schuijers, UMC Utrecht, NL: Targeted perturbation of signaling-driven transcriptional condensates

 

11.30 – 12.10

Tanja Mittag, St. Jude Children's Research Hospital, Memphis, TN: Transcriptional hubs: Biomolecular condensates or higher-order complexes?

 

 

 

12:10 – 13.00

Wrap up and goodbye



ORGANIZERS

The symposium is organized by the CHALLENGE grant consortium REPIN  - Rethinking Protein-Protein Interactions (https://www1.bio.ku.dk/english/research/bms/sbinlab/repin/).

 

Event Location

Click to view the event location on Google Maps >

Organizer Contact Information

University of Copenhagen, Faculty of Science
Caspar Elo Christensen

Phone: +45 35 33 31 66
caspar.christensen@bio.ku.dk

Organizer Contact Information

University of Copenhagen, Faculty of Science
Caspar Elo Christensen

Phone: +45 35 33 31 66
caspar.christensen@bio.ku.dk