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Wednesday August 24, 2022 at 8:00 AM to Friday August 26, 2022 at 1:00 PM
Tuesday August 23, 2022 at 11:00 PM
Novo Nordisk Foundation,
Tuborg Havnevej 19,
2900 Hellerup
Novo Nordisk Foundation
Tuborg Havnevej 19
2900 Hellerup
The Novo Nordisk Foundation and the Department of Biology are pleased to invite you to participate in a three day symposium on transcirption factors and their interactions with special focus on the role of intrinsic disorder. Topics include ensemble characterization, mechanisms, networks, structures, and in vivo function. Accordingly, speakers represent diverse fields such as physics, biochemistry, structural biology, pharmacology, and cell biology. It is a specific aim of the symposium to facilitate intensive discussions among experienced and younger scientists, especially PhD students and postdocs, on central topics as presented by the speakers. Participants are strongly encouraged to bring posters. Based on submitted poster abstracts two younger speakers will be selected for oral presentations.
You are very welcome to advertise the event by printing this poster and putting it on your door. Download the poster here.
A special summer course targeting PhD students is organized in conjunction with the symposium. You can download a flyer for the course here. Accepted applicants for the course receive free seats for the symposium and therefore do not need to register on this page. Instead, please register for the course here.
CONFIRMED SPEAKERS
PROGRAM (download pdf copy here)
DAY 1 |
WEDNESDAY 24 |
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8.00 – 8.30 |
Registration and light breakfast |
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8.30 – 8.35 |
Welcome by the Novo Nordisk Foundation |
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8.35 – 8.40 |
Welcome by REPIN |
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8.40 – 10.25 |
STRUCTURAL ENSEMBLES AND MECHANISMS |
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8.40 – 9.25 |
Peter E. Wright, The Scripps Research Institute, La Jolla, CA: Regulation of transcription by posttranslational modification of disordered domains |
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9.25 – 9.45 |
Selected based on abstracts: Mark Driver, University of Groningen, NL: Elucidating transcription condensate selectivity: a molecular dynamics approach |
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9.45 – 10.25 |
Per Jemth, Uppsala University, Uppsala, SE: Probing protein-protein interactions using an evolutionary approach |
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10.25 – 10.50 |
Coffee break |
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10.50 – 12.35 |
COMPLEXES AND FLEXIBILITY IN COMPLEXES |
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10.50 – 11.30 |
Yuan He, Northwestern University, Evanston, IL: Structural visualization of chromatin regulatory complexes using cryo-EM |
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11.30 – 11.55 |
Pétur Orri Heiðarsson, University of Iceland, Reykjavík, IS: Disordered domains of pioneer transcription factors in chromatin invading and opening |
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11.55 – 12.35 |
Rachel E. Klevit, University of Washington, Seattle, WA: Structure/Not Structure: From Fingers to Fuzz |
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12.35 – 13.25 |
Lunch |
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13.25 – 14.45 |
DNA-BINDING AND GENE SPECIFICITY |
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13.25 – 14.15 |
Naama Barkai, Weizmann Institute of Science, IL: How transcription-factor recognized their binding sites within large genomes |
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14.15 – 14.55 |
Steven Hahn, Fred Hutchinson Cancer Research Center, Seattle, WA: Transcription coactivator mechanisms and gene specificity |
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14.55 – 16.00 |
Coffee and poster session I |
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16.00 – 17.05 |
EMERGING TECHNIQUES |
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16.00 – 16.25 |
Selected based on abstracts: Alexandre M. Erkine, Butler University, IN: Surfactant mechanism of eukaryotic gene activation |
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16.25 – 17.05 |
Gijs Wuite, Vrije Universiteit Amsterdam, NL: Frontiers in Single Molecule manipulation and imaging of DNA-protein transactions |
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17:05 – 18:00 |
Reception |
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DAY 2 |
THURSDAY 25 |
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8.00 – 8.30 |
Light breakfast |
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8.30 – 9.50 |
DETERMINANTS OF ACTIVATION DOMAINS |
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8.30 – 9.10 |
Max Staller, University of California, Berkeley, CA: Sequence features of transcriptional activation domains |
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9.10 – 9.50 |
Xavier Salvatella, IRB Barcelona, Barcelona, ES: Decoding the sequence determinants of activation domains in transcription factors |
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9.50 – 10.10 |
Coffee break |
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10.10 – 12.10 |
(ALLOSTERIC) REGULATION IN DNA-BINDING |
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10.10 – 10.50 |
Vincent J. Hilser, Johns Hopkins University, Baltimore, MD: Frustration in transcription factors provides bi-directional allosteric control. |
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10.50 – 11.30 |
Hagen Hofmann, Weizmann Institute of Science, IL: Rethinking DNA - A phenotype switch driven by DNA-mediated allostery |
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11.30 – 12.10 |
Elisar Barbar, Oregon State University, Corvallis, OR: Protein disorder in transcription factors and gene silencing regulation |
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12.10 – 13.00 |
Lunch |
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13.00 – 14.20 |
DISORDER IN BINDING AND REGULATION |
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13.00 – 13:40 |
Sarah Shammas, University of Oxford, Oxford, UK: Roles of protein disorder in DNA binding domains |
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13.40 – 14.20 |
Robert O.J. Weinzierl, Imperial College London, London, UK: Understanding structure/function relationship in the intrinsically disordered MYC oncoprotein through combined experimental and computational approaches |
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14:20 – 16:00 |
Coffee and poster session II |
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16.00 – 18.00 |
COMPLEXES, NETWORKS AND REGULATION |
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16.00 –16.40 |
Jesper Svejstrup, University of Copenhagen, Copenhagen, DK: Rethinking RNA polymerase II, the ultimate transcription factor |
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16.40 –17.20 |
M. Madan Babu, St. Jude Children's Research Hospital, Memphis, TN: Systems approaches to studying the role of IDRs in transcriptional regulation of gene expression |
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17.20 – 18.00 |
Vaclav Veverka, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, CZ: The role of IDP regions in nucleosome recognition |
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DAY 3 |
FRIDAY 26 |
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8:00 – 8:30 |
Light breakfast |
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8.30 – 9.35 |
DRUG AND DESIGN |
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8.30 – 9.10 |
Sarah Bondos, Texas A&M Health Science Center, Bryan, TX: Shape-shifting disorder to regulate and diversify transcription factor function |
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9.10 – 9.35 |
Joe Rogers, University of Copenhagen, Copenhagen, DK: Rethinking the drug potential of peptides |
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9.30 – 10:10 |
Coffee break |
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10.10 – 12.10 |
CONDENSATES IN TRANSCRIPTIONAL REGULATION |
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10.10 – 10.50 |
Lucia C. Strader, Duke University, Durham, NC: Transcription factor condensation attenuates activity and rewires gene expression |
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10.50 – 11.30 |
Jurian Schuijers, UMC Utrecht, NL: Targeted perturbation of signaling-driven transcriptional condensates |
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11.30 – 12.10 |
Tanja Mittag, St. Jude Children's Research Hospital, Memphis, TN: Transcriptional hubs: Biomolecular condensates or higher-order complexes? |
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12:10 – 13.00 |
Wrap up and goodbye |
ORGANIZERS
The symposium is organized by the CHALLENGE grant consortium REPIN - Rethinking Protein-Protein Interactions (https://www1.bio.ku.dk/english/research/bms/sbinlab/repin/).
Click to view the event location on Google Maps >
University of Copenhagen, Faculty of Science
Caspar Elo Christensen
Phone: +45 35 33 31 66
caspar.christensen@bio.ku.dk
University of Copenhagen, Faculty of Science
Caspar Elo Christensen
Phone: +45 35 33 31 66
caspar.christensen@bio.ku.dk