DAY 1

WEDNESDAY 24

8.00 – 8.30

Registration and light breakfast

8.30 – 8.35

Welcome by the Novo Nordisk Foundation

8.35 – 8.40

Welcome by REPIN

8.40 – 10.25

STRUCTURAL ENSEMBLES AND MECHANISMS

8.40 – 9.25

Peter E. Wright, The Scripps Research Institute, La Jolla, CA: Regulation of transcription by posttranslational modification of disordered domains

9.25 – 9.45

Selected based on abstracts: Mark Driver, University of Groningen, NL: Elucidating transcription condensate selectivity: a molecular dynamics approach

9.45 – 10.25

Per Jemth, Uppsala University, Uppsala, SE: Probing protein-protein interactions using an evolutionary approach

10.25 – 10.50

Coffee break

10.50 – 12.35

COMPLEXES AND FLEXIBILITY IN COMPLEXES

10.50 – 11.30

Yuan He, Northwestern University, Evanston, IL: Structural visualization of chromatin regulatory complexes using cryo-EM

11.30 – 11.55

Pétur Orri Heiðarsson, University of Iceland, Reykjavík, IS: Disordered domains of pioneer transcription factors in chromatin invading and opening

11.55 – 12.35

Rachel E. Klevit, University of Washington, Seattle, WA: Structure/Not Structure: From Fingers to Fuzz

12.35 – 13.25

Lunch

13.25 – 14.45

DNA-BINDING AND GENE SPECIFICITY

13.25 – 14.15

Naama Barkai, Weizmann Institute of Science, IL: How transcription-factor recognized their binding sites within large genomes

14.15 – 14.55

Steven Hahn, Fred Hutchinson Cancer Research Center, Seattle, WA: Transcription coactivator mechanisms and gene specificity

14.55 – 16.00

Coffee and poster session I

16.00 – 17.05

EMERGING TECHNIQUES

16.00 – 16.25

Selected based on abstracts: Alexandre M. Erkine, Butler University, IN: Surfactant mechanism of eukaryotic gene activation

16.25 – 17.05

Gijs Wuite, Vrije Universiteit Amsterdam, NL: Frontiers in Single Molecule manipulation and imaging of DNA-protein transactions

17:05 – 18:00

Reception

DAY 2

THURSDAY 25

8.00 – 8.30

Light breakfast

8.30 – 9.50

DETERMINANTS OF ACTIVATION DOMAINS

8.30 – 9.10

Max Staller, University of California, Berkeley, CA: Sequence features of transcriptional activation domains 

9.10 – 9.50

Xavier Salvatella, IRB Barcelona, Barcelona, ES: Decoding the sequence determinants of activation domains in transcription factors

9.50 – 10.10

Coffee break

10.10 – 12.10

(ALLOSTERIC) REGULATION IN DNA-BINDING

10.10 – 10.50

Vincent J. Hilser, Johns Hopkins University, Baltimore, MD: Frustration in transcription factors provides bi-directional allosteric control. 

10.50 – 11.30

Hagen Hofmann, Weizmann Institute of Science, IL: Rethinking DNA - A phenotype switch driven by DNA-mediated allostery

11.30 – 12.10

Elisar Barbar, Oregon State University, Corvallis, OR: Protein disorder in transcription factors and gene silencing regulation

12.10 – 13.00

Lunch

13.00 – 14.20

DISORDER IN BINDING AND REGULATION

13.00 – 13:40

Sarah Shammas, University of Oxford, Oxford, UK: Roles of protein disorder in DNA binding domains

13.40 – 14.20

Robert O.J. Weinzierl, Imperial College London, London, UK: Understanding structure/function relationship in the intrinsically disordered MYC oncoprotein through combined experimental and computational approaches

14:20 – 16:00

Coffee and poster session II

16.00 – 18.00

COMPLEXES, NETWORKS AND REGULATION

16.00 –16.40

Jesper Svejstrup, University of Copenhagen, Copenhagen, DK: Rethinking RNA polymerase II, the ultimate transcription factor

16.40 –17.20

M. Madan Babu, St. Jude Children's Research Hospital, Memphis, TN: Systems approaches to studying the role of IDRs in transcriptional regulation of gene expression

17.20 – 18.00

Vaclav Veverka, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, CZ: The role of IDP regions in nucleosome recognition

DAY 3

FRIDAY 26

8:00 – 8:30

Light breakfast

8.30 – 9.35

DRUG AND DESIGN

8.30 – 9.10

Sarah Bondos, Texas A&M Health Science Center, Bryan, TX: Shape-shifting disorder to regulate and diversify transcription factor function

9.10 – 9.35

Joe Rogers, University of Copenhagen, Copenhagen, DK: Rethinking the drug potential of peptides

9.30 – 10:10

Coffee break

10.10 – 12.10

CONDENSATES IN TRANSCRIPTIONAL REGULATION

10.10 – 10.50

Lucia C. Strader, Duke University, Durham, NC: Transcription factor condensation attenuates activity and rewires gene expression

10.50 – 11.30

Jurian Schuijers, UMC Utrecht, NL: Targeted perturbation of signaling-driven transcriptional condensates

11.30 – 12.10

Tanja Mittag, St. Jude Children's Research Hospital, Memphis, TN: Transcriptional hubs: Biomolecular condensates or higher-order complexes?

12:10 – 13.00

Wrap up and goodbye